Anlotinib, chemo, and radiation before sarcoma surgery
Treatments studied
Part of Cancer clinical trials.
This trial tests combining anlotinib (a targeted therapy), doxorubicin (chemotherapy), and radiation given before surgery to shrink high-grade soft tissue sarcomas. The goal is to make the tumor easier to remove and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have a high-grade soft tissue sarcoma (like synovial sarcoma, liposarcoma, or leiomyosarcoma) that doctors think can be treated with chemotherapy and radiation.
- Your cancer team has reviewed your case and believes the tumor can be removed with surgery after neoadjuvant treatment.
- You have not had any cancer treatment (chemotherapy, radiation, targeted therapy, or immunotherapy) in the last 4 weeks.
- Your blood counts, kidney function, liver function, and heart function are within a safe range.
- You have no serious heart problems, uncontrolled infections, or bleeding issues.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether giving chemotherapy both before and after surgery helps people with high-risk soft tissue sarcoma live longer and prevents the cancer from coming back. It aims to see if this treatment plan is more effective than surgery alone.
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This trial tests a combination of radiation therapy and two drugs (anlotinib and penpulimab) given before surgery for soft tissue sarcoma. The goal is to see if this approach can shrink tumors and improve outcomes.
This study tests whether giving radiation, chemotherapy, and immunotherapy together can control high-risk soft tissue sarcoma that is hard to remove or may come back after surgery. It may help by attacking cancer in different ways, including boosting the immune system.
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