Genetic test-guided treatment before prostate surgery
Part of Cancer, Kidney & urinary clinical trials.
This trial tests different drugs before prostate surgery based on a person's genetic profile. It aims to find better treatments for high-risk prostate cancer that hasn't spread yet.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a man age 18 or older.
- You have high-risk prostate cancer that has not spread outside the prostate (localized).
- You have not had any prior treatment for prostate cancer, except possibly up to 12 weeks of hormone therapy.
- You have a prostate tissue sample available from a recent biopsy for genetic testing.
- You are in good overall health (ECOG 0 or 1) and expected to live at least 3 more years.
- You do not have serious heart, liver, or other medical conditions that would make surgery unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of hormone therapy, a targeted pill (Darolutamide), and an immunotherapy drug (Pembrolizumab) before and after surgery for men with high-risk prostate cancer that has specific genetic features. The goal is to see if this approach helps prevent the cancer from coming back.
This trial uses genetic test results from your prostate cancer to guide treatment choices. It may help find therapies that better match the specific gene changes in your cancer.
This trial tests a new combination of drugs given before surgery for locally advanced prostate cancer. The goal is to see if giving these drugs first helps shrink the tumor and improves outcomes after surgery.
This study tests whether taking a drug called apalutamide (combined with hormone therapy) after prostate removal helps prevent the cancer from returning. It is for men whose prostate cancer has a high risk of coming back after surgery.
This trial looks for specific DNA repair changes in men with prostate cancer. It tests if these genetic features can help guide treatment decisions. You may join if you have high-risk localized, newly metastatic, or advanced prostate cancer and have tissue available for testing.
This trial studies whether taking talazoparib and enzalutamide before surgery can shrink or control prostate cancer. If treatment works, it may make the cancer easier to remove with a radical prostatectomy.
Hear when a new Prostate cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.