Warm chemotherapy placed in the abdomen to treat colon cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This Phase 3 trial tests whether heating chemotherapy and delivering it directly into the abdomen (along with standard surgery for cancer spread) works better for colon cancer that has spread to the lining of the abdomen. It may help control the cancer after surgery, especially when the spread is mainly in the abdomen (and possibly the liver or lungs).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You can give written consent and are 18 to 78 years old
- Your general health is fairly good (ECOG 0–2 or ability to do daily tasks roughly 60–100 on Karnofsky)
- Your blood, kidney, and liver tests are good enough for chemotherapy
- If you can become pregnant, you have a documented negative pregnancy test
- Your cancer is colon cancer that has spread to the abdomen lining (peritoneum), possibly also the liver (up to 3 spots)
- Doctors think you’re eligible for CRS and HIPEC based on your usual hospital tumor board
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 1 trial tests a treatment that delivers heated chemotherapy directly into the abdomen (HIPEC) for certain cancers that have spread only within the abdominal lining. It aims to see how safely and effectively this approach works, especially when doctors can remove as much tumor as possible.
This trial tests a treatment called HIPEC (heated chemotherapy given directly into the abdomen during surgery) for stomach cancer that has spread to the lining of the belly. The goal is to see if this approach can help remove or shrink the cancer and improve outcomes.
This study tests a personalized way to deliver heated chemotherapy directly into the belly during surgery for advanced appendix or colorectal cancer that has spread to the lining of the abdomen. The goal is to see if tailoring the chemo drugs to your tumor can improve outcomes.
This trial tests putting a chemo drug (fluorouracil) directly into the colon through a tube. It's for people with colorectal cancer who are already getting other cancer treatment, to see if adding local chemo helps shrink the main tumor.
This Phase 2 study tests whether spraying chemotherapy into the abdomen (through a small procedure) after colon cancer surgery can lower the chance the cancer comes back. It is meant for people with high-risk tumor features but who have had surgery and have no proven relapse yet.
This study is an audit (a review of care) of patients who undergo cytoreductive surgery plus heated chemotherapy placed in the abdomen. It helps doctors understand how this treatment is done and what outcomes and safety it has.
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