Test drug heating inside the abdomen for peritoneal cancer
Treatments studied
Part of Cancer, Digestive system, Hormones & metabolism, Women’s health & pregnancy clinical trials.
This Phase 1 trial tests a treatment that delivers heated chemotherapy directly into the abdomen (HIPEC) for certain cancers that have spread only within the abdominal lining. It aims to see how safely and effectively this approach works, especially when doctors can remove as much tumor as possible.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your cancer must be proven by pathology tests as peritoneal cancer from mesothelioma/atypical mesothelial growth, or from appendix, colon, or ovarian cancer.
- Doctors must be able to measure the tumors (or estimate the amount of spread) and you must have a low-to-moderate tumor burden based on a special peritoneal score (PCI).
- You must be healthy enough for surgery and doctors must expect you can remove the tumor completely (completeness score 1 or 0) during the planned procedure.
- You must be at least 18 and have good blood counts and organ function (for example, enough white blood cells and platelets, and kidney/liver function within required limits).
- You must not have spread outside the abdomen (no extra-abdominal metastases).
- If you could become pregnant or father a child, you must use reliable birth control during the study and for 180 days afterward.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 3 trial tests whether heating chemotherapy and delivering it directly into the abdomen (along with standard surgery for cancer spread) works better for colon cancer that has spread to the lining of the abdomen. It may help control the cancer after surgery, especially when the spread is mainly in the abdomen (and possibly the liver or lungs).
This trial uses a test on your tumor tissue to find which chemotherapy drugs work best for you, after standard surgery and heated chemotherapy. It aims to make your treatment more effective by choosing drugs that match your cancer.
This trial tests if giving heated chemotherapy as a mist (aerosol) is better than as a liquid for cancer that has spread to the lining of the abdomen. It is for people who have already had at least three months of standard chemo but still have disease and cannot have surgery right now.
This study tests a personalized way to deliver heated chemotherapy directly into the belly during surgery for advanced appendix or colorectal cancer that has spread to the lining of the abdomen. The goal is to see if tailoring the chemo drugs to your tumor can improve outcomes.
This study tries to better predict how well patients do after heated chemotherapy placed in the abdomen during surgery for stomach or colon cancer that has spread to the lining of the abdomen. It may help doctors choose the best treatment plan and timing for future patients.
This Phase 2 trial tests an intensive treatment for advanced ovarian, fallopian tube, or primary peritoneal cancer. It combines planned surgery to remove visible tumor with chemotherapy that is put directly inside the abdomen during the operation, aiming to control the cancer more effectively.
Hear when a new Peritoneal Mesothelioma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.