Hemoperfusion with Polymyxin B for septic shock after heart surgery
Part of Infections clinical trials.
This trial studies a blood-filter treatment (hemoperfusion with Polymyxin B) to reduce harmful substances in the blood for people who develop septic shock after heart surgery. It may help by lowering inflammation and improving safety, but it also requires meeting specific signs of severe infection and blood/bleeding conditions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be in the ICU after cardiac (heart) surgery and have signs of worsening severe infection (SOFA score higher by 2 points than your previous check)
- Your tests must show strong inflammation/infection signals (procalcitonin above 2 ng/mL and CRP above 150 ng/mL)
- You must be needing a medication to support blood pressure (norepinephrine infusion)
- You must have evidence of infection in blood (a positive blood culture)
- You must not have active bleeding or a history of heparin-induced thrombocytopenia (a dangerous low-platelet reaction to heparin)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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