SOX chemotherapy plus immunotherapy for junction stomach-esophagus cancer
Part of Cancer, Digestive system clinical trials.
This trial studies whether adding an immunotherapy drug (sintilimab) to standard chemotherapy (S-1 and oxaliplatin) can better treat locally advanced cancer at the junction of the esophagus and stomach. It may help shrink the tumor and control the cancer before or around surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have confirmed esophagogastric junction adenocarcinoma that is stage cT3-4a, has lymph node involvement (N+), and has no distant spread (M0)
- You must be able to give signed consent and agree to share tumor tissue from a biopsy or surgery for PD-L1, EBV, and MSI testing
- You must be age 18–75 and able to have the planned surgery (your health must allow abdominal and/or chest surgery)
- Your blood counts and organ tests must be in safe ranges (for example, platelets and white blood cells must be high enough, and liver/kidney/clotting tests must be within limits)
- You must have good general function (ECOG 0–1) and expected survival of at least 6 months
- If you can become pregnant or are able to father a child, you must use effective birth control during treatment and for 6 months after the last dose
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether giving immunotherapy (a treatment that helps your immune system fight cancer) along with chemotherapy and radiation before surgery can help shrink tumors in people with stomach cancer at the esophagus-stomach junction. The goal is to see if this approach is safe and effective before the main surgery.
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