Clin2
NCT05173246Possibly a fitRecruiting

First-line treatment study for advanced small cell esophageal cancer

Esophageal Small Cell Carcinoma

Treatments studied

Part of Cancer, Digestive system clinical trials.

This Phase 2 trial tests JS001 plus TP as a first treatment for people with advanced or unresectable small cell esophageal cancer. It aims to see how well this combination controls the cancer and improves outcomes compared with starting treatment with standard options.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
43 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You’re between 18 and 75 years old.
  • Your cancer is confirmed as small cell cancer of the esophagus, and it can’t be removed by surgery or has spread/returned.
  • You have not had any “systemic” anti-cancer treatment before (treatments that travel through the body).
  • If you previously had chemo with surgery or chemo with radiation for a curative attempt, the cancer must have come back or spread more than 6 months after that treatment ended.
  • You must have at least one measurable tumor spot and be fit for treatment based on standard blood test and heart/lung status (ECOG 0–1).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06478264Not yet recruiting· Phase 2
Immunotherapy plus chemoradiation for esophageal small cell carcinoma

This study tests a combination of an immunotherapy drug (adebrelimab) plus chemotherapy and radiation for esophageal small cell carcinoma. The goal is to see if this combination improves outcomes for patients who have not been treated before.

NCT04989985Recruiting· Phase 2
SOX chemotherapy plus immunotherapy for junction stomach-esophagus cancer

This trial studies whether adding an immunotherapy drug (sintilimab) to standard chemotherapy (S-1 and oxaliplatin) can better treat locally advanced cancer at the junction of the esophagus and stomach. It may help shrink the tumor and control the cancer before or around surgery.

Guangzhou, Guangdong
NCT07533305Not yet recruiting· Phase 2
Combination therapy for advanced esophageal cancer

This trial tests a new combination of drugs (QL1706, nab-paclitaxel, and cisplatin) as a first treatment for advanced or metastatic esophageal squamous cell carcinoma. The goal is to see if this combination is safe and effective in shrinking tumors and helping patients live longer.

NCT07709533Not yet recruiting· Phase 2
Precision treatment for advanced esophageal cancer

This study tests whether choosing a treatment based on specific biomarkers (biological clues) works better than the standard approach for people with advanced esophageal squamous cell carcinoma (a type of esophageal cancer) that has not been treated yet. It aims to improve outcomes by tailoring therapy to each person's cancer.

Guangdong, GUANGZHOU
NCT07251062Not yet recruiting· Phase 2/Phase 3
Combination treatment for advanced esophageal cancer

This trial tests a combination of a new drug (SYS6010), an immunotherapy called enlonstobart, and standard chemotherapy as the first treatment for esophageal squamous cell carcinoma that cannot be removed by surgery or has spread. The goal is to see if this combination helps shrink tumors and improve outcomes.

NCT07484724Recruiting· Phase 2
JS212 combination therapy for advanced esophageal cancer

This trial tests a new combination of drugs (JS212 plus another medicine) for people with advanced esophageal squamous cell carcinoma who have not had prior treatment. It aims to see if the combination is safe and effective.

Beijing, Beijing Municipality

Hear when a new Esophageal Small Cell Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.