Clin2
NCT05206877Possibly a fitRecruiting

Topical insulin eyedrops for glaucoma-related eye nerve damage

Glaucoma

Treatments studied

Part of Eyes & vision clinical trials.

This Phase 1 study tests an insulin-based eye treatment to see if it’s safe and potentially helpful for people with glaucoma-related optic nerve damage. If you may be eligible, you’ll have a close eye exam and repeated vision testing, mainly focused on one study eye.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
52 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You can understand the study and sign informed consent (or have a legally authorized representative).
  • You have optic nerve damage from glaucoma, NAION, or optic disc drusen.
  • Only one eye would be used as the study eye (usually the one with worse vision or visual field).
  • You are not pregnant and not breastfeeding.
  • You do not have other major eye problems causing severe vision loss (like severe uveitis, serious cornea problems, or certain retina/macular diseases).
  • You do not have diabetes or known glucose intolerance (type 1 or type 2).
  • You can do reliable visual field testing and return for required visits and eye tests.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06017362Recruiting· Phase 4
Insulin drops for dry eye in glaucoma patients

This study tests whether insulin eye drops can safely help dry eye in people who also use eye drops for glaucoma. It may offer a new option if you have both conditions and your eye pressure is stable.

Madrid, Madrid
NCT07074782Not yet recruiting
Using eye drops to protect nerve cells in glaucoma

This study looks at whether certain glaucoma eye drops might help protect the nerve cells in your eye over time. If you've been using the same type of eye drop for a few years, researchers will review your past eye tests to see how your vision and eye health have changed.

Bonn
NCT05426044Recruiting· Phase 2
Metformin to protect the optic nerve in glaucoma

This study tests whether metformin can slow damage to the optic nerve in people with glaucoma. It uses eye scans and vision tests to look for changes over time, aiming to help preserve sight.

Wong Chuk Hang
NCT07847073Recruiting· Phase 4
Comparing eye drops for glaucoma and their effect on the optic nerve

This trial tests two eye drops—Rhopressa (netarsudil) and timolol—at lowering eye pressure in people with open-angle glaucoma. The study uses a special camera to see if treatment helps protect the nerve cells in the back of the eye.

Bloomington, Indiana
NCT06806332Not yet recruiting
Glaucoma eye drop aids study

This study tests tools to help you use your glaucoma eye drops correctly. If you've been using the same drops for at least two months, you may be able to join.

Boston, Massachusetts
NCT07425535Recruiting· Early Phase 1
Optic nerve strain study for people without glaucoma

This study looks at how the optic nerve (the part of your eye that sends images to your brain) strains or bends in people who do not have glaucoma. It uses advanced eye imaging and home pressure checks to understand the nerve's health.

Baltimore, Maryland

Hear when a new Glaucoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.