More fluids for children sick with toxin E. coli
Part of Blood & lymphatic, Infections, Kidney & urinary, Women’s health & pregnancy clinical trials.
This study looks at whether giving extra (hyper) fluids early helps children with a high-risk E. coli stomach infection. The goal is to improve outcomes by supporting the kidneys during the illness.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child is between 9 months and under 21 years old
- They have had diarrhea in the last 7 days and it is linked to a high-risk toxin E. coli infection
- They may have bloody diarrhea, or doctors suspect hemolytic uremic syndrome (HUS), or a lab test shows a high-risk E. coli type or Stx2 toxin
- They do not have advanced HUS (all three: low red cell level, low platelets, and high creatinine/kidney level)
- They have not had HUS before, and they do not have atypical HUS
- They are able to take part in the study without language barriers, and your child is not pregnant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new medicine called INM004 in children with STEC-HUS, a serious illness that damages the kidneys and blood cells. It may help speed up recovery and prevent complications.
This study tests a new way to give fluids during sepsis in children to improve blood flow and recovery. It compares a standard saltwater solution to a plasma-based solution to see which works better.
This study looks at how rare gene mutations may explain atypical HUS (aHUS) and how that could guide more personalized treatment. It mainly involves people who have had aHUS affecting blood counts and kidneys.
This study compares two types of IV fluids commonly used to rehydrate young children with gastroenteritis (stomach flu with diarrhea and vomiting). Researchers want to see which fluid works better and causes fewer problems.
This trial tests whether the antibiotic cefotetan works as well as current standard treatments for E. coli bloodstream infections that start in the urinary tract. If you qualify, you may receive either cefotetan or the usual antibiotic therapy.
This study tests a blood-cleaning treatment to remove harmful toxins from the blood of people with severe abdominal infections. It might help their organs recover faster.
Hear when a new Hemolytic-Uremic Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.