Oral antibiotic step-down for ESBL bladder infections
Part of Infections, Kidney & urinary, Women’s health & pregnancy clinical trials.
This Phase 3 trial tests whether switching from short-term IV antibiotics to an oral antibiotic combo is safe and effective for ESBL urine infections. It may help you avoid staying on IV antibiotics as long, if your bacteria are the right match.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You had fever (at least 38.3°C) or shaking chills at least once at home or in the hospital.
- Your doctors suspect a bladder/kidney infection based on symptoms like burning or urgent urination, new/worse leaking, blood in urine, frequent urination, or pain in the lower belly/flank.
- Your urine and/or blood test shows an ESBL bacteria type that is susceptible to pivmecillinam.
- You are an inpatient who has had 1–5 days of an “ESBL-active” IV antibiotic, and your doctor thinks it’s safe to switch to oral antibiotics.
- You have not joined this trial before (one time only).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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