Testing add-on treatments for very treatment-resistant schizophrenia
Part of Mental health clinical trials.
This trial tests a combination of an NMDA-targeting medicine and an anti-inflammatory treatment for people with schizophrenia that has not responded well to several standard treatments, including clozapine. If you qualify, the goal is to see whether this combination improves symptoms more than usual care.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a DSM-5 diagnosis of schizophrenia
- Your illness has not responded well to at least two antipsychotic medicines, and you have also tried clozapine for more than 12 weeks
- You have ongoing symptom scores that are high enough to qualify (PANSS total 70 or higher, and SANS total 40 or higher)
- You can understand study questions and complete the study assessments
- You can legally and safely join the study (agree to consent and follow the plan)
- You are not pregnant or breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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