Trial of your own engineered T cells for ovarian cancer
Part of Cancer, Hormones & metabolism, Women’s health & pregnancy clinical trials.
This Phase 1 study tests whether giving your own immune cells—engineered to target the FSH receptor—can control recurrent ovarian-related cancers. It’s mainly looking at safety and early signs of activity for patients whose cancer has not responded well to standard platinum chemotherapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re age 18 or older and can give informed consent.
- Your cancer diagnosis is confirmed ovarian, primary peritoneal, or fallopian tube cancer (or certain related tumor types), and it is serous/endometrioid/clear cell/mucinous/mixed/undifferentiated (or allowed special subtypes like borderline/sex cord-stromal).
- Your cancer has measurable disease or detectable (non-measurable) disease, and you agree to provide a tumor sample for extra lab testing.
- You’ve had treatment with platinum chemotherapy before, and your cancer either keeps growing during it (platinum-refractory) or returns within 6 months after it (platinum-resistant).
- You’re well enough to travel through treatment (ECOG 2 or better or Karnofsky ≥60%) and expected to live at least 3 months; your organ labs (bone marrow, kidneys, liver) are within allowed ranges.
- For safety, you must avoid certain recent treatments: no chemotherapy/biologic/immunotherapy in the 3 weeks before the T-cell infusion, no immune “checkpoint” drugs in the 3 months before, and you must stop hormone therapy (if you’re on it) at least 1 week before the T-cell infusion.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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