Testing an anti-depression medicine for threat-related brain changes in teens
Part of Mental health clinical trials.
This trial studies how fluoxetine or escitalopram (anti-depression medicines) may affect brain systems involved in feeling threatened and staying anxious when you have depression. It also uses brain scanning and blood tests to measure these changes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 14 and 21 years old, and past puberty (Tanner stage above 3)
- Have depression as your main mental health diagnosis (not another primary diagnosis)
- Be able to agree and follow study tasks, and have a caregiver consent if needed
- Be under a clinician’s care who will treat you with fluoxetine or escitalopram
- Not take medicines that could interfere—especially antidepressants, mood stabilizers, hormone supplements, or steroids—for the required washout time
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a common medication called fluoxetine (often used for depression) affects how young adults understand social situations. It may help researchers learn more about how this medicine works on the brain.
This study tests a new type of brain stimulation called accelerated intermittent theta burst stimulation (aiTBS) in young people (ages 13-20) with depression who have not tried many treatments before. The goal is to see if this treatment can safely help reduce depression symptoms.
This study looks at how anxiety in young teens might lead to substance use later. It uses brain scans and stress tests to understand these pathways.
This trial tests if a gentle electrical brain stimulation called tACS can help teens with depression who are already on stable medication. The treatment is added to their usual medication to see if it improves mood.
This trial tests a faster version of a brain stimulation treatment called intermittent theta-burst stimulation (iTBS) for teenagers with depression. The treatment uses magnetic pulses to stimulate the brain and may help improve mood when medication alone isn't enough.
This study tests a new type of brain stimulation called TMS (transcranial magnetic stimulation) for young people ages 15-25 who are having serious depression and suicidal thoughts. The goal is to see if this treatment can help reduce risk and improve mood.
Hear when a new Depression in Adolescence trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.