Clin2
NCT05361720Possibly a fitRecruiting

Genetic test to match treatment for advanced kidney cancer

Advanced Clear Cell Renal Cell CarcinomaMetastatic Clear Cell Renal Cell CarcinomaStage III Renal Cell Cancer AJCC v8Stage IV Renal Cell Cancer AJCC v8

Treatments studied

Part of Cancer, Kidney & urinary, Women’s health & pregnancy clinical trials.

This study looks at genetic (RNA) testing of kidney cancer tissue to help choose the best drug treatment. It may help guide therapy for people with advanced or metastatic clear cell kidney cancer who are starting treatment for the first time.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
54 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have kidney cancer (clear cell type) confirmed by pathology (biopsy/surgery tissue results).
  • Your cancer is advanced or has spread (metastatic) and cannot be cured with surgery or radiation.
  • You have not had any drug treatment for kidney cancer before in the advanced/metastatic setting.
  • Your scans show at least one measurable spot the doctors can track on treatment.
  • You can provide tumor tissue for RNA testing, and it must come from suitable soft tissue around bone (bone-only tissue is not accepted).
  • Your general health is good enough (Karnofsky performance score of 70% or higher), and your blood tests and organ function meet limits.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04981509Recruiting· Phase 2
Check if 3 medicines help advanced kidney cancer

This Phase 2 trial tests whether combining bevacizumab, erlotinib, and atezolizumab can shrink or control advanced kidney cancer. It’s aimed at people with certain kidney-cancer subtypes (including HLRCC-related cases or papillary kidney cancer) and who have not had many prior targeted or immune treatments.

La Jolla, California
NCT06399419Recruiting· Phase 1
Study of CBM588 with immunotherapy for advanced kidney cancer

This trial tests whether adding a probiotic (CBM588) to a standard immunotherapy combination (nivolumab and ipilimumab) helps treat advanced kidney cancer. It is for people with a specific type of kidney cancer that has spread or cannot be removed with surgery, who have not had systemic treatment before.

Duarte, California
NCT07776717Not yet recruiting· Phase 2
Immunotherapy plus targeted therapy for advanced kidney cancer

This trial tests a combination of two drugs — an immunotherapy (toripalimab) and a targeted therapy (axitinib) — as the first treatment for advanced kidney cancer. The approach may shrink the tumor before deciding whether and when to remove the kidney surgically.

NCT06870279Not yet recruiting· Phase 1
A new immune cell therapy for advanced kidney cancer

This trial tests an experimental therapy using special immune cells engineered to target a protein called CD70 on kidney cancer cells. It may help patients whose cancer has returned or spread after previous treatment.

NCT07383441Recruiting· Phase 3
Adding Biotherapy or Placebo to Standard Kidney Cancer Treatment

This trial tests whether adding a biotherapy (a special drug from a living source) or a placebo to standard treatments helps people with advanced kidney cancer. It may be a good option if your cancer hasn't been treated yet and you are in fairly good health.

Fayetteville, Arkansas
NCT07877194Not yet recruiting· Phase 2
Study of two drug combinations for advanced kidney cancer

This trial tests two combinations of investigational drugs for people with advanced clear cell kidney cancer that cannot be removed with surgery. The goal is to see if these combinations can shrink or control the cancer.

Los Angeles, California

Hear when a new Advanced Clear Cell Renal Cell Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.