Ustekinumab for painful Crohn’s bowel narrowing
Treatments studied
Part of Digestive system clinical trials.
This trial tests ustekinumab, a medicine that calms immune inflammation, to see if it can improve symptoms in people with Crohn’s disease that causes bowel narrowing. It may help if your Crohn’s symptoms come from strictures (narrowed areas) seen on scans or endoscopy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a doctor’s diagnosis of moderate to severe Crohn’s disease
- In the past 8 weeks, you’ve had obstructive (blockage-like) symptoms
- Imaging or endoscopy must show one or more Crohn’s strictures (narrowings)
- Your strictures were not recently treated with a stricture procedure or surgery in the last 6 months
- You have no urgent need for surgery or endoscopy within the next 2 months (as your clinician judges)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two medicines, Guselkumab and Ustekinumab, for people with Crohn's disease that causes narrowing (strictures) in the bowel. It aims to find which works better to improve symptoms and avoid the need for more procedures.
This trial tests whether risankizumab can help people with a type of Crohn's disease where the intestine becomes narrowed (fibrostenotic) and causes symptoms like cramping or vomiting. The goal is to see if the drug can reduce inflammation and improve these blockages.
This study looks at how well ustekinumab works on its own for people with perianal fistulizing Crohn's disease, a type of Crohn's that causes painful tunnels near the anus. If you are already taking ustekinumab without other Crohn's medicines, this trial may help show if it can improve your fistulas.
This trial tests a new way to treat narrowed areas (strictures) in the bowel caused by inflammatory bowel disease. A soft metal tube called a stent is placed using a scope to open the narrowing and relieve symptoms, which may help avoid surgery.
This study looks at inflammation just before a narrowed section of the bowel in people with Crohn’s disease, using planned endoscopic balloon dilation. It may help doctors better understand what drives narrowing and inflammation so treatment can be timed and chosen more effectively.
This Phase 1 study uses a special camera to track how ustekinumab (a common biologic medicine) spreads in inflamed tissue. It aims to help researchers understand where the drug goes in Crohn’s disease and psoriasis, especially when standard treatments haven’t worked.
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