Oral PHA-022121 extension for hereditary angioedema attacks
Treatments studied
Part of Genetic & congenital, Heart & circulation, Immune system & allergy, Skin clinical trials.
This study is an extension trial of an oral medicine (PHA-022121) for treating acute attacks in people with hereditary angioedema (HAE), especially HAE type III (HAE-nC1INH). It checks whether continuing this oral treatment can safely help manage attacks after you’ve taken it before.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You (or your parent/guardian if under 18) sign consent, and older teens may need to assent.
- You must have taken study drug in a previous related study (or be a specific eligible adolescent who completed it).
- If you can become pregnant: agree to pregnancy tests and use approved contraception (or avoid heterosexual intercourse) until 30 days after your last dose.
- You must be able/willing to follow all study instructions and attend visits.
- You must have HAE type III (HAE-nC1INH) and meet special lab and diagnosis rules, including C1 inhibitor function and C4 blood level results.
- Your attacks must have not improved with certain other medicines, and you must have proven relief with on-demand icatibant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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