Insula brain stimulation for long-term nerve pain
Part of Brain & nervous system, Pain clinical trials.
This trial tests whether stimulating a specific brain area (the insula) can reduce chronic nerve pain. It is for people whose pain has lasted at least 6 months and has not improved enough with several pain medicines and other procedures.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re age 18 to 80 and can give consent and attend all study visits
- Your pain has lasted at least 6 months and is severe, disabling, and stable for the last 2 months
- Your pain is nerve-related (for example after stroke, spinal cord injury, or shingles) rather than from an “unknown” cause
- You tried at least 3 prescription pain medicines at proper doses, including one opioid at some point, without enough relief
- Your MRI shows the insula brain area clearly enough for doctors to place electrodes during testing
- Your heart, MRI safety, bleeding risk, and seizure history fit the study’s safety rules
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether stimulating two brain networks with implanted electrodes can relieve chronic nerve pain that hasn't responded to other treatments. It is for people with severe pain lasting more than six months.
This Phase 2 study looks at how spinal cord (or nerve-root) stimulation affects pain signals in the brain and body. You may qualify if you already have a stimulator set to a comfort mode that avoids “tingling” sensations.
This trial studies whether changing the “stimulation pattern” of spinal cord stimulation can reduce long-lasting pain and improve daily function. You might be a good candidate if you have chronic trunk or leg pain and have already tried multiple pain treatments without enough relief.
This study is for people who are planning to get a device implanted that delivers stimulation to the brain or nerves. The trial tests whether different stimulation settings work better, which could improve symptom control for participants.
This study tests a device that delivers mild electrical stimulation to the brain from home to help reduce chronic nerve pain. It focuses on people whose pain has not improved enough despite stable pain medicines.
This study tests a type of brain stimulation called Temporal Interference Stimulation (TIS) to see if it can help reduce nerve pain. It may be an option if you have had nerve pain for at least a month and it is moderate or worse.
Hear when a new Neuropathic Pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.