Clin2
NCT05404581Possibly a fitRecruiting

Insula brain stimulation for long-term nerve pain

Neuropathic PainChronic Pain

Part of Brain & nervous system, Pain clinical trials.

This trial tests whether stimulating a specific brain area (the insula) can reduce chronic nerve pain. It is for people whose pain has lasted at least 6 months and has not improved enough with several pain medicines and other procedures.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
12 people
Ages
18 years to 80 years
Study type
Interventional

Who can take part

  • You’re age 18 to 80 and can give consent and attend all study visits
  • Your pain has lasted at least 6 months and is severe, disabling, and stable for the last 2 months
  • Your pain is nerve-related (for example after stroke, spinal cord injury, or shingles) rather than from an “unknown” cause
  • You tried at least 3 prescription pain medicines at proper doses, including one opioid at some point, without enough relief
  • Your MRI shows the insula brain area clearly enough for doctors to place electrodes during testing
  • Your heart, MRI safety, bleeding risk, and seizure history fit the study’s safety rules

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07057206Not yet recruiting· Phase 1
Brain stimulation study for hard-to-treat chronic pain

This study tests a device implanted in the brain that may reduce long-lasting nerve pain that has not improved with other treatments. It could help people with pain after nerve injury, stroke, or other conditions.

Minneapolis, Minnesota
NCT05661903Recruiting· Phase 2
Spinal cord stimulator study for nerve pain and brain effects

This Phase 2 study looks at how spinal cord (or nerve-root) stimulation affects pain signals in the brain and body. You may qualify if you already have a stimulator set to a comfort mode that avoids “tingling” sensations.

Boston, Massachusetts
NCT05968664Recruiting
Test whether new spinal cord stimulation settings improve chronic pain

This trial studies whether changing the “stimulation pattern” of spinal cord stimulation can reduce long-lasting pain and improve daily function. You might be a good candidate if you have chronic trunk or leg pain and have already tried multiple pain treatments without enough relief.

Houston, Texas
NCT02346396Recruiting
At-home brain stimulation trial for long-lasting nerve pain

This study tests a device that delivers mild electrical stimulation to the brain from home to help reduce chronic nerve pain. It focuses on people whose pain has not improved enough despite stable pain medicines.

Bron
NCT07735975Not yet recruiting
Brain stimulation for nerve pain relief

This study tests a new type of non-invasive brain stimulation, called temporal interference stimulation (TIS), to see if it can help relieve nerve pain that has not improved with standard treatments. If it works, it might offer a drug-free option for controlling chronic nerve pain.

NCT07798908Not yet recruiting· Phase 1
Brain stimulation for chronic nerve pain

This study tests a non-invasive brain stimulation technique (using magnetic pulses) to see if it can change how the brain values and processes chronic pain, potentially helping to reduce pain.

Bethesda, Maryland

Hear when a new Neuropathic Pain trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.