Cisplatin heated during surgery or before surgery for advanced ovarian cancer
Treatments studied
Part of Cancer, Hormones & metabolism, Women’s health & pregnancy clinical trials.
This early-phase study tests whether giving cisplatin (a chemotherapy drug) heated in the abdomen during surgery—or giving cisplatin before surgery—can improve treatment for stage III or IV ovarian, fallopian tube, or peritoneal cancer. It’s designed for people who are having surgery after several cycles of standard chemotherapy and may benefit from a better cancer-killing approach at the time of tumor removal.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 years or older and able to read and understand consent forms in English
- Have newly diagnosed stage III or IV epithelial ovarian, fallopian tube, or peritoneal cancer
- Plan to receive (or have already received) chemotherapy before surgery (neoadjuvant chemo) because complete tumor removal was not feasible at first
- Have completed 3 cycles of standard chemotherapy (carboplatin plus paclitaxel every 3 weeks) and show at least a 50% CA-125 drop by before surgery
- Be healthy enough for major surgery: good blood counts, kidney function (creatinine clearance over 60), and stable heart/liver tests (AS A 1–2; ECOG 0–2)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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