Probiotic rinse to treat chronic sinus inflammation
Treatments studied
Part of Ear, nose & throat clinical trials.
This Phase 2 study tests whether washing your sinuses with a probiotic solution can improve chronic sinusitis symptoms and inflammation. It’s for adults with chronic sinus symptoms that have flared, especially if you’ve had sinus surgery in the past.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 18 or older.
- You have chronic sinusitis with a recent flare-up—worse nasal blockage, discharge, facial pressure/pain, or reduced sense of smell—plus endoscopy findings showing inflammation and/or infection.
- You had functional endoscopic sinus surgery more than 12 months ago, and your treating clinician believes your sinuses are suitable for this trial.
- You are willing and able to follow the study plan, including filling out questionnaires during the study.
- You agree to sign informed consent after learning the purpose and procedures of the study.
- You are not currently using (or won’t stop) topical antibiotic sinus rinses, and you are not pregnant or breastfeeding (if applicable).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two kinds of nasal rinse packets—xylitol versus plain saline—to see which better reduces sinus symptoms. It may help adults with cystic fibrosis and long-term sinus inflammation feel better with routine, at-home nasal care.
This trial studies whether placing a steroid nasal cream inside your sinus area can reduce symptoms in people with chronic rhinosinusitis (CRS) even after sinus surgery. It may help lower ongoing inflammation and symptoms for those who still feel unwell despite usual medical treatments.
This trial tests if transplanting healthy nasal bacteria from a donor can help people with chronic sinusitis. It aims to restore a healthy microbiome in the nose to reduce symptoms like congestion and discharge.
This study tests if using a nebulizer to deliver steroid spray can help people with chronic sinusitis (CRS) without prior sinus surgery. It focuses on improving symptoms like nasal congestion and facial pressure.
This study tests a new sinus stent that slowly releases medicine to treat chronic sinusitis in both nostrils. The goal is to see if it helps reduce symptoms and inflammation better than usual care.
This trial tests if rinsing the sinuses with a mixture of povidone-iodine (an antiseptic) and budesonide (a steroid) after endoscopic sinus surgery can improve outcomes for people with chronic sinusitis.
Hear when a new Chronic Rhinosinusitis (Diagnosis) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.