Baricitinib to help reduce HIV in the brain
Treatments studied
Part of Immune system & allergy, Infections clinical trials.
This Phase 2 study tests baricitinib to see if it can lower HIV activity in the brain (CNS) for people already on stable HIV treatment. If you have well-controlled HIV in your blood, this trial looks for additional benefit inside the nervous system.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old
- Your HIV is well controlled on continuous ART: viral load below 200 copies/mL for at least 12 months
- Your CD4 count is above 350 for at least 12 months while on treatment
- You are not pregnant and not breastfeeding; if you can become pregnant, you must use effective birth control
- You have no major blood count problems on screening (low white cells, low hemoglobin, or low platelets)
- You do not currently have certain serious infections or recent sick illnesses (including untreated tuberculosis and active herpes symptoms)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a pill called baricitinib (already used for arthritis) to see if adding it to your HIV medications can help control the virus long-term. You might join if your HIV is well controlled and you are generally healthy.
This Phase 2 study looks at whether lowering inflammation can help improve depression symptoms in adults living with HIV. You may be able to join if your HIV is well controlled and you are currently experiencing major depression (or a certain type of bipolar depression).
This trial tests whether a medication that targets inflammation in the body can help relieve depression symptoms. You will have blood tests and an MRI to see how your brain and immune system respond.
This study tests two drugs, baricitinib and sirolimus, alone or together, to see if they can help control HIV after you stop your usual HIV medications for a short time. The goal is to see if these drugs can keep the virus from rebounding.
This study tests whether combining two drugs, ibalizumab and chidamide, can reduce the hidden HIV in your body. It aims to see if this combination is safe and might help control HIV better.
This trial tests whether baricitinib, a pill that lowers inflammation, can also help reduce blood-clotting risk in people with rheumatoid arthritis. It may help if your arthritis is still active despite current treatment, and you have no other major health conditions.
Hear when a new Human Immunodeficiency Virus trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.