Release or sham surgery for clogged celiac artery
Part of Digestive system, Genetic & congenital, Heart & circulation clinical trials.
This trial studies whether a surgical “release” of the celiac artery (to improve blood flow) helps people with MALS who have specific symptoms and artery narrowing. Some people will have a sham (placebo) procedure to compare outcomes, so you’ll be closely monitored either way.
Summary written for real people, not researchers, by Clin2.
Who can take part
- A team of specialists at two Dutch centers has confirmed you have MALS (Median Arcuate Syndrome) after reviewing your case together
- You have pain after eating, plus at least two of: diet changes, unexplained weight loss, or unexplained diarrhea
- Imaging shows a strong narrowing (at least 70%) in the celiac artery near the diaphragm muscle band, confirmed by two different scans (with detailed breathing views for one scan)
- Your abdominal ultrasound and upper scope (gastroscopy) don’t show other common causes of your symptoms, aside from possible irritation from poor blood flow
- You are not pregnant, have not had prior procedures on the gut arteries, and you’re not able to have this surgery through an endoscopic approach; also your other gut arteries aren’t significantly narrowed
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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