Study JCXH-212 to treat advanced solid tumors safely
Part of Cancer clinical trials.
This early trial tests whether JCXH-212 alone, or with toripalimab (an immunotherapy drug), is safe and tolerable in people with advanced solid cancers. It also looks at whether treatment can help by targeting tumor “neoantigens” found in your tumor tissue.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 to 75 years old
- Have advanced solid cancer that has come back, progressed, or you could not tolerate standard treatment (exact details depend on which part of the study)
- You can provide tumor biopsy tissue for neoantigen testing (needed to see if the vaccine target is present)
- Be in generally good health with performance status (ECOG) 0 to 1, and expect to live more than 3 months
- Have at least one measurable tumor spot on scans, and meet blood counts and organ-function blood test limits (bone marrow, kidney, liver, and clotting tests)
- Not have certain brain metastasis or other uncontrolled/unstable medical problems, and previous treatment side effects must have mostly improved before starting
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial is testing an experimental therapy (JCXH-211) that is injected directly into the tumor, combined with an immunotherapy drug (anti-PD-1 antibody). It is for people with advanced solid tumors who have not had success with standard treatments, and it aims to help the immune system fight the cancer more effectively.
This trial tests two new drugs, JS212 and JS213, alone or together, for people with certain advanced cancers that have stopped responding to standard treatments. The goal is to see if these drugs can shrink tumors or slow cancer growth.
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