New treatment plan for older adults with newly diagnosed AML
Part of Blood & lymphatic, Cancer clinical trials.
This trial studies a two-part chemotherapy plan for older adults newly diagnosed with acute myeloid leukemia (AML) who can’t take the usual standard induction treatment. It aims to improve how well treatment works while taking into account age and other health conditions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have newly diagnosed AML confirmed by biopsy or bone test, not the APL subtype
- You are age 60 or older, and you can likely live more than 3 months
- You have not had AML treatment yet, and you’re not able to receive standard induction chemo (often due to age or other illnesses)
- Your kidney and liver tests are within study limits (or changes are thought to be from the leukemia itself)
- You have manageable performance status (ECOG 2 or less) and can give informed consent
- Your heart rhythm and major organs are stable enough for this chemotherapy plan
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This Phase 2 trial tests whether adding three medicines—venetoclax, chidamide, and azacitidine—can help adults whose AML has come back or did not respond to treatment. It may help shrink or control the leukemia and improve outcomes for people who fit the study’s health and lab requirements.
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This trial tests a combination of four drugs (venetoclax, azacitidine, chidamide, and CAG chemotherapy) to treat newly diagnosed acute myeloid leukemia (AML—a blood cancer) in adults aged 60–75. The goal is to see if this combination helps patients live longer and feel better.
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