Ibuprofen vs PSA blood test for prostate evaluation
Treatments studied
Part of Cancer, Kidney & urinary clinical trials.
This trial studies whether an anti-inflammatory medicine (ibuprofen) changes prostate-specific antigen (PSA) blood test results to help decide on next diagnostic steps like MRI or biopsy. It may help people with an elevated PSA understand whether follow-up testing is more or less likely to be needed.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be a man age 18 to 80 with a PSA blood test result above 3 (ng/mL)
- Have had a normal prostate rectal exam within the last 2 years
- Have no symptoms or recent test results suggesting a urinary infection (like burning or smelly urine)
- You cannot have an allergy to ibuprofen or other non-steroidal anti-inflammatory drugs (NSAIDs)
- You must not have certain bleeding problems, serious kidney disease (eGFR under 30), or major heart disease/poorly controlled high blood pressure
- You cannot currently be on certain meds (like blood thinners/dual antiplatelets, steroids/anti-inflammatory drugs, or finasteride/dutasteride unless used for 6+ months) and must not have had prostate MRI/biopsy in the past year
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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