Treatment
Ibuprofen clinical trials
We’re tracking 43 recruiting studies that include Ibuprofen, each written for real people, not researchers, below.
Recruiting studies
- NCT04059172RecruitingEarly Phase 1
Ibuprofen plus acetaminophen for braces pain
This early study compares braces pain relief using: ibuprofen alone, ibuprofen plus acetaminophen together, or placebo (no active pain medicine). It may help find which approach works best and is safest for people starting orthodontic treatment.
Aurora, ColoradoAges 12–80 - NCT07459049RecruitingPhase 4
Ibuprofen for gum inflammation after deep cleaning
This trial tests whether ibuprofen can help calm gum inflammation after a deep cleaning for periodontitis. It is for adults with moderate-to-severe gum disease who are otherwise healthy.
BaghdadAges 18 years+ - NCT07143201RecruitingPhase 2
Precision dosing of ibuprofen for PDA in premature babies
This study tests a personalized way to give ibuprofen to very premature babies with a heart condition called PDA. It aims to see if adjusting the dose can help close the heart opening more safely.
Hamilton, OntarioAges Up to 6 months - NCT06980870RecruitingPhase 2
Pain medicine before root canal for less discomfort
This study tests whether taking ibuprofen or dexamethasone before a root canal can help reduce pain afterward. It's for people with a painful, inflamed tooth nerve who haven't already taken pain medicine for it.
RawalpindiAges 18–50 - NCT05340582RecruitingPhase 2
Ibuprofen plus acetaminophen for a heart condition in very premature babies
This Phase 2 study tests whether giving ibuprofen together with acetaminophen improves outcomes for an important heart connection (PDA) in extremely premature infants. It compares how this medicine approach affects the baby’s heart-related measurements and short-term progress.
Newcastle, New South WalesAges Up to 6 months - NCT05919745RecruitingPhase 4
Ibuprofen before mouth surgery to reduce pain sensing
This trial studies whether taking ibuprofen before tooth extraction and bone graft surgery can lower how much pain you feel afterward. It may help by changing the body’s pain response during healing.
Milwaukee, WisconsinAges 18 years+ - NCT07145645RecruitingPhase 3
Comparing topical diclofenac to oral ibuprofen for pain from ankle or knee injuries in children
This study compares a topical gel (diclofenac) applied directly to the injury site versus an oral medication (ibuprofen) taken by mouth to see which works better for treating pain from ankle or knee injuries in children. It may offer a way to relieve pain without a pill.
Calgary, AlbertaAges 6–18 - NCT07070050RecruitingPhase 4
NSAIDs after laparoscopic surgery: continuous or bolus?
This study compares giving NSAID pain relievers continuously through an IV versus as single doses (bolus) after laparoscopic surgery to find which method provides better pain relief with fewer side effects.
Moscow, Moscow OblastAges 18 years+ - NCT06088732RecruitingPhase 1/Phase 2
Exercise and ibuprofen for bipolar depression
This study tests whether acute exercise and ibuprofen can improve symptoms of bipolar depression by studying their effects on the immune system and brain circuits. It may help if you are currently in a depressive episode and can do moderate physical activity.
Tulsa, OklahomaAges 18–55 - NCT07024199RecruitingPhase 4
Pain relief for children with acute pancreatitis
This trial compares three common pain relievers (paracetamol, ibuprofen, and metamizole) to see which works best for children with acute pancreatitis. It aims to help your child feel better faster with fewer side effects.
WarsawAges 3–18 - NCT03055247RecruitingPhase 2
Try ibuprofen plus growth factor and stem-cell mobilizer for X-CGD
This trial tests a combination of medicines to help your body release (“mobilize”) stem cells for future treatment in people with X-linked chronic granulomatous disease (X-CGD). If it works well and is safe for you, it may make stem-cell collection easier and more successful.
Rome, LazioAges 18–45 - NCT05721027RecruitingPhase 4
Ibuprofen alone or with a steroid for new sciatica pain
This trial compares ibuprofen alone versus ibuprofen plus dexamethasone (a steroid) for short-term relief of acute nerve-related low back pain that shoots into the buttock or leg. It aims to see which approach reduces pain and improves function after an emergency visit.
The Bronx, New YorkAges 18–70 - NCT03476577Recruiting
Bariatric surgery study measuring how ibuprofen is absorbed
This study looks at how ibuprofen is absorbed by the body around the time of bariatric (weight-loss) surgery. It may help doctors understand how to use pain medicine safely and effectively after surgery.
TrondheimAges 18–70 - NCT04102566RecruitingPhase 4
Better pain control during TURP surgery
This trial tests whether a pain-control approach can make TURP (prostate surgery through the urine tube) more comfortable. It may help you manage pain with the study medicines during and after your procedure.
Seattle, WashingtonAges 18 years+ - NCT07824258RecruitingPhase 1
Pain relief study after vasectomy
This study tests whether a pain-relief method helps reduce discomfort after a vasectomy. It may help you recover more comfortably.
New York, New YorkAges 18–65 - NCT05629494RecruitingPhase 4
Ibuprofen vs PSA blood test for prostate evaluation
This trial studies whether an anti-inflammatory medicine (ibuprofen) changes prostate-specific antigen (PSA) blood test results to help decide on next diagnostic steps like MRI or biopsy. It may help people with an elevated PSA understand whether follow-up testing is more or less likely to be needed.
Chicago, IllinoisAges 18–80 - NCT07672418Recruiting
Pain relief after tonsil surgery: ibuprofen vs. ketorolac
This study compares two common pain relievers (ketorolac and ibuprofen) given after tonsil/adenoid surgery in teenagers. It aims to see which works better while keeping side effects low.
Houston, TexasAges 13–18 - NCT07632274RecruitingPhase 1
Testing a pain reliever liquid for children ages 6–11
This study tests a new liquid medicine that combines ibuprofen and acetaminophen (two common over-the-counter pain relievers) in children aged 6 to 11. Researchers want to see how well the medicine works and how safe it is for mild to moderate pain, such as headaches, toothaches, or pain after dental work or vaccines.
Salt Lake City, UtahAges 6–11 - NCT07603934RecruitingEarly Phase 1
Testing Medications Inside Root Canals to Reduce Pain
This study tests different medications placed inside a tooth's root canal during treatment to see which one best reduces pain afterward. If you have a tooth with a dead nerve (necrotic pulp), this trial might help determine the best way to manage your pain during the healing process.
Cairo, Cairo GovernorateAges 18–40 - NCT07571252RecruitingPhase 4
Pain Relief Before Jaw Surgery: A Study
This study tests whether taking pain medicine before jaw surgery (orthognathic surgery) helps reduce pain after the procedure. If you're having jaw surgery, this trial may help doctors understand the best way to manage your pain.
San JuanAges 21–65 - NCT07487246RecruitingPhase 2
Pain relief study for abortion dilator placement
This study tests whether combining two medications (lidocaine and ketorolac) given as a shot around the cervix can help with pain when placing small sticks (dilators) to prepare for an abortion procedure. If you are 16–24 weeks pregnant and planning an abortion, this trial may help you feel less discomfort.
Chicago, IllinoisAges 18 years+ - NCT07410078Recruiting
Comparing medicines given before surgery for children
This trial compares different medicines given by mouth before surgery to see which works best to help children relax and have less pain. If your child is having day surgery, this study might help find the best pre-surgery medicine for them.
AnkaraAges 4–12 - NCT07393503Enrolling by invitationPhase 4
Pain relief for new muscle and joint injuries
This trial compares two common treatments for new muscle or joint pain: an over-the-counter pain reliever (Tylenol and ibuprofen) versus an oral steroid (a stronger anti-inflammatory medication). The goal is to see which option works better for short-term pain and recovery.
Buffalo, New YorkAges 18 years+ - NCT07374354Recruiting
Pain and anxiety control for kids with MIH
This study tests a pain-relieving medicine given before dental treatment to see if it helps reduce pain and anxiety in children with molar incisor hypomineralization (MIH), a condition that causes weak enamel on molars and front teeth.
GizaAges 6–12
What Ibuprofen is being studied for
Conditions with recruiting Ibuprofen studies.
Common questions
- Are there clinical trials studying Ibuprofen?
- Yes. Clin2 currently lists 43 recruiting studies that include Ibuprofen, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Ibuprofen trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Ibuprofen an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Ibuprofen or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.