Clin2
NCT05703672Possibly a fitRecruiting

Switching smokers to e-cigarettes who do not want to quit

Smoking Reduction

Treatments studied

Part of Lungs & breathing clinical trials.

This study tests whether switching from regular cigarettes to e-cigarettes helps smokers who are not interested in quitting. You would also be offered varenicline and regular check-ins to compare outcomes over time.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
500 people
Ages
21 years and older
Study type
Interventional

Who can take part

  • You are at least 21 years old
  • You smoke more than 5 cigarettes per day and have been smoking for over 6 months
  • You must be a confirmed smoker (they check with a breath test called carbon monoxide)
  • You are interested in switching to e-cigarettes and you agree to take varenicline and attend all visits
  • You must have a working phone and live in the Kansas City metro area during the study period
  • Your household cannot already have someone enrolled in this study

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05555069Recruiting
Menthol-flavored vaping study for adult menthol cigarette smokers

This study looks at how menthol flavoring may affect whether adult menthol cigarette smokers switch to e-cigarettes. You may be asked to switch and use e-cigarettes over a set period, while researchers track your smoking behavior.

Kansas City, Missouri
NCT06260683Recruiting
Comparing tobacco vs. non-tobacco flavored e-cigarettes for quitting smoking

This study tests whether using e-cigarettes with a tobacco flavor or a non-tobacco flavor helps people who smoke switch away from regular cigarettes. Participants will use either e-cigarettes or nicotine replacement therapy for a period of time, and researchers will track their smoking behavior.

Columbus, Ohio
NCT06373679Recruiting
Switch or Quit: A study for smokers who want to quit

This study helps adults 21 and older who have tried to quit smoking with a stop-smoking medication. You may be able to join if you want to try quitting again or want to reduce harm from tobacco.

Charleston, South Carolina
NCT05257629Recruiting· Phase 3
Aggressive smoking quit program after heart problems

This trial tests whether a strong quit plan using varenicline (a quit pill) plus nicotine e-cigarettes, along with counseling, helps people stop smoking after a recent heart-related event. It’s aimed at people who want to quit and can safely stay involved for about a year.

New Westminster, British Columbia
NCT07040566Recruiting· Phase 2
Varenicline to help stop vaping

This trial tests whether varenicline, a medicine that reduces cravings, can help people quit using e-cigarettes that contain nicotine. You must be a daily nicotine vaper and live in Connecticut or South Carolina.

New Haven, Connecticut
NCT06688539Recruiting· Phase 4
Quitting e-cigarettes in adults who also use cannabis

This trial tests if varenicline, a stop-smoking medication, can help people ages 18 to 40 quit e-cigarettes while also using cannabis. It's designed for regular e-cigarette users who want to quit and who use cannabis at least 10 days per month.

Charleston, South Carolina

Hear when a new Smoking Reduction trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.