Clin2
NCT05772845Possibly a fitRecruiting

Study of quitting support for vaping and smoking withdrawal

Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)

Part of Lungs & breathing clinical trials.

This study looks at nicotine withdrawal symptoms in people who vape and/or smoke regularly. It may help improve how quitting support is tailored, based on how participants respond during the withdrawal period.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
370 people
Ages
21 years to 50 years
Study type
Interventional

Who can take part

  • You’ve used nicotine vaping and/or cigarettes most days for at least 6 months
  • A quick nicotine test (cotinine) shows levels of nicotine in your body (200+ ng/mL)
  • You do not plan to quit daily/near-daily vaping or smoking within the next month
  • You have not used other tobacco/nicotine products (like hookah, smokeless tobacco, nicotine pouches) in the last week, and the study requires specific rules about cigars/pipe/hybrid products
  • You are not taking any smoking-cessation medicine, and you are not currently pregnant
  • You are not dealing with severe substance dependence (other than tobacco/nicotine), and you do not have current suicidal thoughts with intent/plan

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06944847Recruiting
Vaping and smoking study for people with schizophrenia

This study looks at habits of vaping and smoking in people with schizophrenia. It may help researchers understand how to better support people who want to reduce or quit nicotine use.

Buffalo, New York
NCT06619964Enrolling by invitation
Study on nicotine levels in e-liquids

This trial tests how different nicotine levels in e-liquids affect people who use pod or pen-style vapes daily. It aims to help regulators make better rules about nicotine content.

Rochester, New York
NCT06066996Recruiting· Early Phase 1
Study of withdrawal symptoms when people vape less

This study looks at what happens when people who vape nicotine daily try to cut back. Researchers want to understand withdrawal symptoms and find better ways to help people reduce or quit vaping.

Baltimore, Maryland
NCT07786896Not yet recruiting· Phase 4
Quitting vaping with nicotine replacement therapy

This study tests whether nicotine replacement therapy (like patches or gum) helps people who regularly vape nicotine stop vaping. If you're interested in quitting in the next few months, this study may be able to support you.

Greenville, North Carolina
NCT07322432Recruiting· Phase 2
The CONQUER trial: quitting vaping with e-cigarette reduction

This study tests whether gradually reducing nicotine in e-cigarettes helps people who vape quit completely. It is for adults who are ready to stop and want a structured program.

New York, New York
NCT07739797Not yet recruiting
Study on nicotine from e-cigarettes and cigarettes

This study looks at how nicotine from e-cigarettes is absorbed by the body compared to regular cigarettes. It may help if you are a daily smoker who also uses e-cigarettes or just smokes cigarettes, and you are willing to stay in a clinic for 10 days.

Hear when a new Acute Abstinence From Cigarettes vs E-cigarettes (ENDS) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.