Personalized 5-FU dosing for advanced gastrointestinal cancer
Part of Cancer, Digestive system clinical trials.
This study tests whether doctors can safely find the best dose of 5-FU, a chemotherapy medicine, for people with advanced gastrointestinal cancers. The goal is to reduce side effects while still treating the cancer effectively.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 18 or older
- You have advanced or spreading gastrointestinal cancer (including colon/rectum or cancers of the stomach, esophagus, appendix, small bowel, or ampulla)
- You can have scans of the chest, abdomen, and pelvis within the last 30 days
- Your overall activity level is good (ECOG 0–1, meaning you can do most daily activities)
- You have not had certain prior chemotherapy: oxaliplatin or fluoropyrimidine chemotherapy (5-FU–type) besides special “radiation-sensitizing” use, and no systemic chemo in the last 6 months
- You do not have specific genetic or safety risks (no mismatch repair deficiency/MSI-high, no DPD deficiency), and your blood tests and organ tests are high enough
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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