Longer vs shorter antibiotic prevention after pancreatoduodenectomy
Treatments studied
Part of Cancer, Digestive system, Hormones & metabolism, Infections clinical trials.
This trial compares a standard length of preventive antibiotics versus a longer course after Whipple surgery to see if it lowers infection risk without causing extra side effects. It targets people considered higher risk for contamination of bile during surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You are having an elective Whipple procedure (pancreatoduodenectomy)
- Your surgery is considered higher risk for contaminated bile (for example, you had preoperative biliary drainage or you have an ampulla cancer)
- You are not pregnant
- You can safely take the trial antibiotics (no allergy or intolerance)
- You are not already planning antibiotic treatment for an infection before surgery (like cholangitis or a liver abscess)
- Your kidney function is normal enough for the study (eGFR is 60 or higher)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether taking a probiotic (a helpful bacteria) before and after surgery to remove part of the pancreas can improve recovery. It is for people who are having this surgery and have not had chemotherapy or radiation beforehand.
This study tests whether a special nutrition plan before and after Whipple surgery (a major operation for pancreatic or bile duct cancer) helps patients recover faster and feel better. Researchers want to see if eating the right nutrients beforehand makes surgery easier on your body.
This study tests whether a shorter course of antibiotics after Whipple surgery works as well as the standard longer course to prevent infections. It aims to reduce unnecessary antibiotic use and side effects.
This study tests whether giving antibiotics for a longer time after pancreatic surgery helps prevent infections. If you had a stent placed to drain bile before surgery, you may be eligible.
This trial is testing whether draining the main pancreatic and bile ducts during a Whipple procedure can lower the risk of a pancreatic leak. The study focuses on people with a higher chance of this complication.
This trial tests if using antiseptic-coated stitches during pancreatic surgery can reduce the chance of a pancreatic leak (fistula) afterward. If you are scheduled for a Whipple procedure (pancreatoduodenectomy), this study may help improve your recovery.
Hear when a new Pancreatic cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.