Stool transplant for long-term inflamed pouch after surgery
Treatments studied
Part of Digestive system clinical trials.
This early-phase study tests fecal microbiota transplant (a stool-based treatment) to improve chronic pouchitis symptoms in adults after UC-related surgery. It may help by changing gut bacteria, especially for people who need ongoing antibiotics or keep having flare-ups.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and have ulcerative colitis (UC)
- You had UC surgery that removed the colon (total proctocolectomy) and created an ileal pouch (IPAA)
- You have chronic pouchitis that fits one of these: antibiotic-dependent (can’t stay off antibiotics), antibiotic-refractory (antibiotics don’t help), or Crohn’s-like pouch inflammation with ongoing treatment and persistent symptoms
- Your current symptoms match the trial’s symptom severity score (mPDAI) requirements doctors use
- You are not allergic to vancomycin or metronidazole, or to ingredients used in the transplant
- You do not have active infection/fever and you are not currently on certain immune medicines, steroids, or other investigational drugs
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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