Lowering steroids with mycophenolate and tacrolimus for lupus kidneys
Treatments studied
Part of Immune system & allergy, Kidney & urinary, Skin, Women’s health & pregnancy clinical trials.
This study tests whether using mycophenolate mofetil plus tacrolimus can help people with lupus nephritis safely lower (taper) their prednisone to a low dose. It is designed for people whose kidney lupus has been well-controlled for at least 6 months.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have systemic lupus with lupus kidney involvement (lupus nephritis) and it has been in remission for at least 6 months
- Your urine protein is very low (24-hour urine protein ≤ 0.5 g/day) and your kidney function is stable or improving
- Your prednisone (or equivalent steroid) dose is at or below 5 mg per day
- Your lupus disease activity is very low right now, and your doctor says the target is met
- You can take mycophenolate mofetil and tacrolimus without allergy or bad side effects
- You are not pregnant (and not planning pregnancy), and you have no serious organ complications or active major lupus problems
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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