Stem cell treatment for complex anal fistulas
Part of Digestive system clinical trials.
This trial compares two types of stem cell treatments to help heal complex anal fistulas (abnormal tunnels near the anus). You may be eligible if your Crohn’s-related disease is mostly controlled and the fistula has not fully healed with standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a complex anal fistula from Crohn’s disease that is difficult to heal
- Your Crohn’s disease is inactive or only slightly active while on usual treatment or biologic therapy
- Imaging (MRI) shows the fistula has effective drainage, and it has a limited number of openings
- Your fistula continues even after the internal opening(s) have tried to close
- You are able to receive this treatment (you are not pregnant or breast-feeding)
- You do not have known allergy to Alofisel, bovine products, or the treatment ingredients
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether injecting donated stem cells into complex anal fistulas can help heal them in people with Crohn's disease. You may qualify if you have a fistula that hasn't improved with standard treatments.
This trial tests whether a special tissue therapy can help heal complex anal fistulas that involve a large part of the sphincter muscle. It is for adults who need surgery for this condition and do not have certain other health issues.
This Phase 1 study tests whether a donated-cell treatment (given with a minor procedure) can help heal simple anal fistulas. It mainly focuses on safety first, but may also look at how well the fistula closes.
This Phase 2 trial studies whether a local injection of fat-derived cells (made from your own tissue) can improve difficult Crohn’s disease fistulas around the anus. It’s designed for people whose Crohn’s fistulas have not responded to usual treatments.
This study follows people having surgery for an anal fistula to see how well they recover. It uses your feedback to measure results, and you'll have check-ins for a year.
This trial tests if a special stem cell treatment (called DB-3Q bmMSC-EVs) can help heal fistulas caused by Crohn's disease. It's for people who have already tried other treatments and still have actively draining fistulas.
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