Stem cells for Crohn's fistula treatment
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether injecting donated stem cells into complex anal fistulas can help heal them in people with Crohn's disease. You may qualify if you have a fistula that hasn't improved with standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have Crohn's disease that is under control (low disease activity) for at least 3 months
- You have a chronic anal fistula with up to 2 internal openings and 3 external openings
- You have tried standard treatments (drainage with setons and anti-TNF therapy) but they didn't work after 6 months
- You have had a colonoscopy within the past year showing no rectal ulcers
- You are not pregnant, breastfeeding, or planning to become pregnant, and use effective birth control if needed
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares two types of stem cell treatments to help heal complex anal fistulas (abnormal tunnels near the anus). You may be eligible if your Crohn’s-related disease is mostly controlled and the fistula has not fully healed with standard treatments.
This Phase 2 trial studies whether a local injection of fat-derived cells (made from your own tissue) can improve difficult Crohn’s disease fistulas around the anus. It’s designed for people whose Crohn’s fistulas have not responded to usual treatments.
This early-phase study tests whether a stem cell transplant can improve Crohn’s disease in teens and young adults whose disease is active and not responding to standard medicines. It may help some people who are not doing well despite several prior treatments, but it also involves intensive study procedures and safety checks.
This Phase 2 study tests whether a transplant using your own stem cells can calm active Crohn’s disease that hasn’t improved with standard medicines. It may help some people with ongoing inflammation and symptoms after multiple Crohn’s treatments.
This trial tests whether a stem cell transplant from a partially-matched family or unrelated donor can help treat severe Crohn's disease that has a known or suspected genetic cause or does not get better with standard treatments.
This trial tests if a special stem cell treatment (called DB-3Q bmMSC-EVs) can help heal fistulas caused by Crohn's disease. It's for people who have already tried other treatments and still have actively draining fistulas.
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