Immunotherapy plus chemotherapy for moderate-risk GTN
Treatments studied
Part of Cancer, Women’s health & pregnancy clinical trials.
This trial tests a combination of an immunotherapy drug (toripalimab) and a chemotherapy drug (actinomycin-D) as the first treatment for gestational trophoblastic neoplasia (GTN) with a FIGO score of 5-6. It may help patients whose disease is at a moderate risk level.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be diagnosed with a specific type of gestational tumor (GTN) that is not another rare type (PSTT or ETT).
- Your FIGO score must be 5 or 6 — this is a number that tells how advanced the disease is.
- You cannot have had any chemotherapy, immunotherapy, or radiation therapy before joining this trial.
- You must be between 18 and 60 years old and healthy enough to get out of bed (ECOG score 0-2).
- Your blood counts, liver, kidney, and thyroid function must be within a safe range.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a combination of two drugs — toripalimab (an immunotherapy) and actinomycin-D (chemotherapy) — as the first treatment for a specific type of pregnancy-related tumor (GTN) with a FIGO score of 7. The goal is to see if this combination works better than standard treatment.
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This trial is creating a database for women diagnosed with gestational trophoblastic neoplasia (GTN), which includes tumors that can develop after a molar pregnancy or other pregnancy-related conditions. By joining, you help researchers better understand and improve treatment for these rare tumors.
This study looks at giving pembrolizumab (a type of immune treatment) before a second evacuation procedure in people with persistent or returning molar pregnancy cancer. The goal is to see if this approach is safe and feasible, and whether it may help control the disease.
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