Thyroid hormone plus letrozole for PCOS and mild hypothyroidism
Treatments studied
Part of Cancer, Hormones & metabolism, Women’s health & pregnancy clinical trials.
This trial tests whether adding a low-dose thyroid hormone (levothyroxine) to the standard fertility treatment letrozole improves pregnancy rates in women with both PCOS and mild hypothyroidism. It may help if you have trouble getting pregnant and have these two conditions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 20 and 40 years old.
- You have a body mass index (BMI) between 18 and 35.
- You have been diagnosed with PCOS (polycystic ovary syndrome) and have a mild form of low thyroid function called subclinical hypothyroidism (TSH 5-10 mIU/L).
- You have been trying to get pregnant for at least 12 months.
- Your male partner has normal sperm, and you have no other known cause of infertility (like blocked tubes, severe endometriosis, or ovarian failure).
- You are not currently taking thyroid medication or any other treatments for thyroid disease.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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