Nano Knife and Immunotherapy for Metastatic Colorectal Cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a treatment that uses tiny electric pulses to destroy liver tumors (NanoKnife) combined with immunotherapy to boost your immune system against cancer. It's for people with colorectal cancer that has spread to the liver and hasn't responded enough to chemotherapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have colorectal cancer that has spread to the liver, with at least one tumor smaller than 3.5 cm that can be completely destroyed.
- Your primary colon or rectal cancer must have been removed with surgery.
- The liver tumors must be considered inoperable, and you must have had chemotherapy but it didn't make them small enough for surgery.
- Your cancer must have been stable for at least 2 months while on your current treatment (no new growth).
- You must have a specific tissue marker (MSI-stable) and a particular blood type marker (HLA-A1 or HLA-A2).
- You cannot have cancer spread to your bones, brain, or the lining of your belly, and you must not have cirrhosis, active autoimmune disease, or major heart problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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