Clemastine for myelin repair in multiple sclerosis
Treatments studied
Part of Brain & nervous system clinical trials.
This trial tests if clemastine fumarate, an antihistamine, helps repair myelin (the protective coating around nerves) in people with relapsing-remitting MS. You'd take the drug and have special MRI scans to see if your brain lesions improve.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have relapsing-remitting MS and were diagnosed less than 15 years ago
- You are between 18 and 55 years old
- Women must use effective birth control, be postmenopausal for at least 1 year, or be surgically sterile
- You are not currently taking steroids (like prednisone) or other myelin repair drugs
- You have no recent new brain lesions (on MRI within 3 months) or significant brain shrinkage
- You do not have severe disability, cancer, heart block, or other major health issues
- You can have an MRI without metal in your body (no braces, implants, etc.)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This early-phase study tests whether clemastine (a drug being studied for “myelin repair”) changes how MS looks on special MRI scans. It may help researchers understand if the treatment supports restoring nerve covering in people with relapsing-remitting MS.
This Phase 2 trial tests whether clemastine can help regrow the protective covering around the optic nerve after acute optic neuritis (an inflammation-related vision problem). It may help improve vision recovery and signal how well “remyelination” happens.
This trial tests a treatment for brain injury in premature babies born before 32 weeks. It aims to protect and repair white matter, the part of the brain that helps nerve cells communicate.
This study tests if adding clemastine (an allergy medication) to standard antidepressants can improve brain health and boost treatment response in adults over 60 with depression.
This study tests whether a common antihistamine (clemastine) combined with aerobic exercise can improve memory and thinking problems in people with schizophrenia. It aims to help the brain's myelin repair and may offer a new treatment option for cognitive symptoms.
This study tests whether N-acetyl cysteine (a supplement-like medicine) changes body and brain function in people with multiple sclerosis. It may help researchers understand how it affects brain chemistry and activity using special brain imaging.
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