CAR-T therapy targeting CLDN18.2 and PD-L1 for advanced solid tumors
Part of Cancer clinical trials.
This trial tests a new type of cell therapy (CAR-T) that targets two proteins, CLDN18.2 and PD-L1, found on some cancer cells. It is for people with advanced solid tumors like stomach, esophageal, or pancreatic cancer that have stopped responding to standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 18 and 75 years old
- Have advanced gastric, esophageal junction, or pancreatic cancer that has progressed after at least one standard treatment
- Your tumor must have at least 10% of cells with the CLDN18.2 protein (tested by biopsy)
- Be well enough to have an ECOG performance status of 0 or 1 (able to carry out daily activities)
- Not have had prior CAR-T or similar cell therapy
- Not have active infections like hepatitis B or C, or HIV
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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