Clin2
NCT07266311Possibly a fitNot yet recruiting

Car-t cell therapy for Claudin 18.2 positive advanced tumors

Claudin18.2 Positive Advanced Solid Tumors

Part of Cancer clinical trials.

This trial tests a special type of immune therapy called CAR-T, which uses your own blood cells to attack cancer cells that have a specific marker, Claudin 18.2. It may be an option for people with advanced solid tumors (especially pancreatic cancer) that have not responded to other treatments.

Summary written for real people, not researchers, by Clin2.

Phase
Early Phase 1
Enrollment
18 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You must be between 18 and 75 years old.
  • You must have advanced cancer that has not responded to at least 2 prior treatments (or at least 1 prior treatment for advanced pancreatic cancer).
  • Your tumor must test positive for a protein called Claudin 18.2.
  • You must have measurable tumors (visible on scans).
  • You need to be in fairly good physical shape (able to do most daily activities).
  • You cannot have brain metastases, active infections, or certain other health conditions.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06782425Recruiting· Phase 1
Cell therapy for advanced stomach cancer with Claudin18.2 protein

This trial tests a new type of cell therapy (CAR-T) that targets a protein called Claudin18.2 found on some stomach, esophagus, and gastroesophageal junction cancers. The goal is to see if this treatment can shrink tumors or stop them from growing when other treatments have stopped working.

Anyang, Henan
NCT06084286Recruiting· Phase 1
CAR-T therapy targeting CLDN18.2 and PD-L1 for advanced solid tumors

This trial tests a new type of cell therapy (CAR-T) that targets two proteins, CLDN18.2 and PD-L1, found on some cancer cells. It is for people with advanced solid tumors like stomach, esophageal, or pancreatic cancer that have stopped responding to standard treatments.

Chengdu, Sichuan
NCT05620732Recruiting
CAR-T treatment for advanced stomach or pancreatic cancer

This trial tests a customized immune-cell treatment (CAR-T) for advanced stomach or pancreatic cancer that cannot be removed by surgery. It aims to use cells engineered to target a specific tumor marker to shrink cancer or slow its growth.

Shenzhen, Guangdong
NCT07416240Recruiting· Early Phase 1
Targeted immune cell therapy for Claudin18.2-positive advanced pancreatic cancer

This early-phase trial is testing a new kind of immune cell therapy—dendritic cells and CAR-T cells—that specifically targets a protein called Claudin18.2 on your cancer cells. It is for people with advanced pancreatic cancer who have already tried standard treatments.

Haikou, Hainan
NCT06946615Recruiting· Phase 1
Claudin18.2 cell therapy for advanced colorectal cancer

This study tests a new treatment using your own immune cells (called CAR-T and CAR-DC) that are engineered to attack cancer cells with a specific protein (Claudin18.2). It is for people with advanced colorectal cancer who have exhausted standard treatments.

Hangzhou, Zhejiang
NCT07680257Recruiting· Early Phase 1
CLDN18.2 CAR T cells for advanced solid tumors

This trial tests a new treatment called CLDN18.2 CAR T cells in people with advanced solid tumors that have a specific marker (CLDN18.2). It aims to see if it is safe and works against cancers that have not responded to standard treatments.

Hefei, Anhui

Hear when a new Claudin18.2 Positive Advanced Solid Tumors trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.