Endoscopic treatment for ongoing acid reflux symptoms
Part of Digestive system clinical trials.
This trial tests a new endoscopic procedure called anti-reflux mucosal ablation therapy to reduce acid reflux in people who still have symptoms despite taking acid-reducing medication. The goal is to see if this treatment helps improve heartburn and related symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You have had acid reflux symptoms for at least 6 months and have been taking acid-reducing medication (like omeprazole) for that time, but your symptoms (like heartburn or acid reflux) have not fully resolved.
- You must have had a pH test (a special test that measures acid in your esophagus) showing your acid exposure is high enough (more than 6% of the time).
- You cannot be pregnant, have severe obesity (BMI of 35 or higher), have a large hiatal hernia, or have certain esophagus conditions like Barrett's esophagus with dysplasia, narrowing, or abnormal motility.
- You must not have had previous anti-reflux surgery or stomach surgery, and no history of cirrhosis, bleeding disorders, or active cancer in the last 2 years.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares a new procedure called anti-reflux mucosal valvuloplasty (ARMV) to acid-reducing medicines (PPIs) for treating GERD. It may help people who have had reflux for a long time and need daily PPIs.
This trial is testing a device called RefluxStop™ that is implanted during keyhole surgery to treat acid reflux (GERD). The study will check how safe and effective the device is for people with long-term GERD, and it aims to help reduce heartburn and other reflux symptoms.
This study looks at how following specific diet and behavior changes affects symptoms of acid reflux (heartburn/regurgitation) in everyday life. It may help you understand what lifestyle steps improve reflux and how symptoms change over time.
This study tests a comprehensive program that combines diet and lifestyle changes to help people with chronic acid reflux (heartburn, acid regurgitation, or chest pain) feel better. It looks at how these changes can improve your overall health and reduce symptoms.
This trial tests a new way to treat GERD (chronic acid reflux) using a tiny camera and a device that delivers a gentle heat treatment (argon plasma coagulation) to the area where the stomach meets the esophagus. It's compared to a 'sham' procedure (you won't know which you get) to see if it stops acid from backing up better than medicine alone.
This study tests a new endoscopic procedure to help people with severe acid reflux that hasn't improved with strong medications. The procedure tightens the valve between the stomach and esophagus to reduce acid backing up.
Hear when a new GERD trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.