Glofitamab with chemo for Richter syndrome
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a new drug called glofitamab combined with standard chemo-immunotherapy (rituximab or obinutuzumab plus CHOP) for people with Richter syndrome, an aggressive lymphoma that arises from CLL. The goal is to see if the combination is safe and effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have Richter syndrome (CLL that has turned into an aggressive B-cell lymphoma) proven by a biopsy.
- You must be between 18 and 80 years old.
- Your overall health status should allow you to be up and about (ECOG score 0-2).
- You need at least one measurable tumor (on CT or PET scan) or lymphoma cells in your bone marrow.
- Your blood counts (neutrophils, hemoglobin, platelets) must be at safe levels, unless due to bone marrow involvement.
- Your heart, liver, and kidney function must be adequate (heart pumping strength over 50%, kidney clearance over 40 mL/min).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests a combination of two oral drugs (nemtabrutinib and pembrolizumab) for people with Richter transformation, an aggressive lymphoma that develops from chronic lymphocytic leukemia. It may be an option if standard chemotherapy is not suitable or if prior treatment has stopped working.
This trial tests adding the targeted drug pirtobrutinib to standard chemotherapy for people with newly diagnosed Richter transformation (when CLL changes into a fast-growing lymphoma). The goal is to see if this combination works better than chemo alone.
This Phase 2 trial studies acalabrutinib, venetoclax, and durvalumab together for Richter transformation (a more aggressive lymphoma) that developed from CLL or SLL. The goal is to improve how well treatment works and how long people can respond.
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