External fixator vs antibiotic-coated plate for severe open bone fractures
Part of Infections, Injuries & trauma clinical trials.
This trial compares two ways to stabilize severe open fractures of the long bones (like the thigh or upper arm): an external fixator (a frame outside the skin) or a metal plate coated with antibiotics placed inside the body. The goal is to find out which approach leads to better healing and fewer infections.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have a severe open fracture (a break in the bone that goes through the skin) that is type IIIA or IIIB according to the Gustilo-Anderson classification.
- The fracture must be in a long bone (such as the thigh, shin, or upper arm) and can be treated with either a plate or an external fixator.
- Your wound must be able to be closed at the time of surgery, or closed later with a skin graft or flap, or heal on its own.
- You must not have a traumatic brain injury, spinal cord injury, or severe burns.
- You must not have a history of allergy to ceftriaxone or sulbactam (antibiotics).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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