Clin2
NCT04678154Possibly a fitRecruiting

Antibiotic trial for severe open fractures of the leg or foot

Post Operative Surgical Site Infection

Part of Infections, Injuries & trauma clinical trials.

This trial tests a new way of giving antibiotics to people with severe open fractures in the leg, ankle, or foot. The goal is to see if it helps prevent infections after surgery.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
600 people
Ages
18 years to 64 years
Study type
Interventional

Who can take part

  • You have a severe open fracture of the tibia, ankle, calcaneus, or talus that needs special wound care.
  • You are between 18 and 64 years old.
  • You may have other health issues like diabetes or a weak immune system.
  • You may have a brain injury or other fractures.
  • You can speak English or Spanish.
  • You are not pregnant, and you can come for follow-up appointments.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT03713528Enrolling by invitation· Phase 4
Antibiotic placed in bone to help save an infected knee implant

This trial tests whether putting antibiotics directly inside the bone during surgery can improve outcomes for an infected knee prosthesis when the implant is being kept. It may help more people avoid needing full implant removal and replacement.

San Francisco, California
NCT05699174Recruiting· Phase 3
Compare two antibiotic routes for infected broken bones after surgery

This Phase 3 trial tests whether giving antibiotics by mouth (PO) works as well as giving antibiotics through a vein (IV) for an infected fracture that has not healed after prior surgery. It may help you understand which approach is safer and more effective for getting the bone to heal.

Indianapolis, Indiana
NCT05157126Recruiting· Phase 4
Gentamicin antibiotic study for open tibia fractures

This trial tests whether a gentamicin antibiotic approach helps heal certain open tibia (shin bone) fractures while lowering infection risk. It focuses on adults with specific types of open, mostly closable tibia wounds treated within set time limits.

Dar es Salaam
NCT03765567Recruiting· Phase 4
Antibiotic powder placed in certain emergency open fractures

This study tests whether putting antibiotic powder directly into an open fracture wound in the emergency room can improve care outcomes. It focuses on adults treated shortly after injury.

San Antonio, Texas
NCT05502380Recruiting· Phase 3
Antibiotic prevention study for high-risk bone and spine surgeries

This Phase 3 study tests whether giving a broad set of preventive antibiotics before certain high-risk orthopedic surgeries lowers the chance of serious wound or bone infection. It mainly targets people who have contaminated wounds, tumor-related surgery, or known high-risk germs on the skin.

Zurich
NCT06193330Not yet recruiting
External fixator vs antibiotic-coated plate for severe open bone fractures

This trial compares two ways to stabilize severe open fractures of the long bones (like the thigh or upper arm): an external fixator (a frame outside the skin) or a metal plate coated with antibiotics placed inside the body. The goal is to find out which approach leads to better healing and fewer infections.

Owo, Ondo State

Hear when a new Post Operative Surgical Site Infection trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.