Antibiotics vs. placebo for simple appendicitis
Treatments studied
Part of Digestive system, Infections clinical trials.
This study tests whether taking antibiotics by mouth at home works as well as placebo (a dummy pill) to treat uncomplicated appendicitis. It might help you avoid surgery and recover without a hospital stay.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 60 years old
- You have a CT scan showing simple (not complicated) appendicitis
- You do not have a fever over 100.4°F (38°C)
- You are not pregnant, breastfeeding, or have certain conditions that prevent a CT scan
- You do not have a severe illness (like cancer or an immune-suppressing condition)
- You are not allergic to moxifloxacin and do not take certain other medicines
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether taking antibiotics alone can treat acute uncomplicated appendicitis, compared with a placebo. If antibiotics work, it may help some people avoid surgery or reduce treatment intensity.
This study tests whether children with early appendicitis (inflammation of the appendix) can be treated safely with antibiotics instead of surgery. Researchers want to see if antibiotics work as well as surgery while avoiding the risks of an operation.
This study tests whether antibiotics are necessary for mild diverticulitis or if a placebo works just as well. Participants are treated in the emergency department and followed using a smartphone app.
This study compares whether you need antibiotics after laparoscopic surgery for a complicated, “localized” appendix infection. It aims to find the safest, most effective antibiotic approach after surgery.
This study looks at why antibiotics might not work for some people with mild appendicitis. It aims to find which patients are better off having surgery instead.
This study compares two ways to treat appendicitis that has formed an abscess or firm inflammatory mass (phlegmon) on a CT scan. It aims to see which approach works better and is safer for people with complicated appendicitis.
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