Antibiotics versus placebo for uncomplicated appendicitis
Treatments studied
Part of Digestive system, Infections clinical trials.
This trial tests whether taking antibiotics alone can treat acute uncomplicated appendicitis, compared with a placebo. If antibiotics work, it may help some people avoid surgery or reduce treatment intensity.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 60 years old.
- Your appendicitis was confirmed by a CT scan as “uncomplicated.”
- You can understand the study and sign informed consent.
- You are not pregnant and not breastfeeding.
- You do not have an allergy to contrast dye/iodine used for CT scans.
- You are not allergic to antibiotics and have no reason you cannot take antibiotics.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial looks at whether different ways of diagnosing appendicitis (like CT scans) are accurate. It's for people who already had surgery to remove their appendix and want to help doctors learn more.
This study tests whether taking antibiotics by mouth at home works as well as placebo (a dummy pill) to treat uncomplicated appendicitis. It might help you avoid surgery and recover without a hospital stay.
This study tests whether children with early appendicitis (inflammation of the appendix) can be treated safely with antibiotics instead of surgery. Researchers want to see if antibiotics work as well as surgery while avoiding the risks of an operation.
This trial tests a newer, less invasive procedure called ERAT against standard laparoscopic appendectomy for adults with a first episode of uncomplicated appendicitis. The goal is to see which approach works better with fewer risks.
This study tests whether antibiotics are necessary for mild diverticulitis or if a placebo works just as well. Participants are treated in the emergency department and followed using a smartphone app.
This study compares whether you need antibiotics after laparoscopic surgery for a complicated, “localized” appendix infection. It aims to find the safest, most effective antibiotic approach after surgery.
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