Predicting when antibiotics alone work for early appendicitis
Treatments studied
Part of Digestive system, Infections clinical trials.
This study looks at why some people with uncomplicated appendicitis get better with antibiotics alone, while others still need surgery. If you join, researchers will track your treatment to find patterns that help predict success, aiming to help more patients avoid surgery in the future.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 16 and 60 years old.
- You have been diagnosed with acute (sudden) appendicitis that is not complicated (no rupture, no abscess, no stones).
- You do not have inflammatory bowel disease (like Crohn's or ulcerative colitis).
- You are not pregnant or breastfeeding.
- You do not have serious kidney problems (creatinine above 150) or diabetes.
- You do not have a bleeding disorder and are not on blood thinners.
- You have no severe allergies to antibiotics or to contrast dye used in imaging.
- You have not had your appendix removed before.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares giving antibiotics for one day versus five days after surgery to remove a non-complicated appendix. The goal is to see if a shorter course works just as well, which could mean fewer side effects and less antibiotic resistance.
This trial compares two treatments for uncomplicated appendicitis: taking antibiotics or having surgery to remove the appendix. It aims to see which option works better and respects your choice.
This trial tests whether taking antibiotics alone can treat acute uncomplicated appendicitis, compared with a placebo. If antibiotics work, it may help some people avoid surgery or reduce treatment intensity.
This study compares two common ways to treat a simple (uncomplicated) appendix problem in children: using antibiotics versus having surgery to remove the appendix. The goal is to see which approach works better and helps children recover faster.
This study compares two ways to treat appendicitis that has formed an abscess or firm inflammatory mass (phlegmon) on a CT scan. It aims to see which approach works better and is safer for people with complicated appendicitis.
This trial looks at patients with a type of appendicitis where there is an abscess or phlegmon (a pocket of pus or swollen tissue) near the appendix. It tests what happens when these patients have surgery right away instead of trying antibiotics or drainage first, to see if this is a safe and effective choice.
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