Combination therapy for advanced MSS, RAS-mutated colorectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a new combination of three medicines for people with a certain type of advanced colorectal cancer that has not been treated before. It aims to see if adding an immunotherapy drug (Cadonilimab) to standard chemotherapy and a targeted therapy (Bevacizumab) can help shrink tumors and delay disease progression.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to 75 years old
- You have advanced colorectal cancer that has spread and cannot be removed by surgery
- Your tumor is MSS-type and has a RAS mutation
- You have not received any prior cancer treatment for this advanced stage
- You have at least one tumor that can be measured on scans and has not been treated with radiation
- You do not have an active autoimmune disease that requires treatment
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a combination of two drugs (cadonilimab and an anti-angiogenic agent) for advanced colorectal cancer that has a specific genetic feature (dMMR or MSI-H). It aims to find a new treatment option that might work better than current therapies.
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