Short radiation plus combo therapy for advanced rectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a short course of radiation therapy followed by a combination of three drugs (fruquintinib, adebrelimab, and CAPOX chemotherapy) before surgery for people with locally advanced rectal cancer. The goal is to see if this approach can shrink the tumor and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have rectal cancer that is locally advanced (spread nearby but not to distant organs).
- You are between 18 and 75 years old.
- Your tumor is within 10 cm of the anal opening (measured by MRI).
- You have not had any prior treatment for rectal cancer (surgery, chemo, radiation, etc.).
- You are in good general health (able to perform daily activities, normal organ function).
- You are willing to use effective birth control during and for 6 months after the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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