Clin2
NCT06014944Possibly a fitNot yet recruiting

Short radiation with targeted drugs for rectal cancer

Rectal Cancer

Part of Cancer, Digestive system clinical trials.

This trial tests a new combination of short-course radiation, a targeted drug (fruquintinib), and an immunotherapy drug (PD-1 inhibitor) to treat rectal cancer before surgery. It aims to shrink the tumor and improve outcomes for patients with a specific type of rectal cancer.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
30 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You are between 18 and 75 years old.
  • You have been diagnosed with a type of rectal cancer called 'pMMR' or 'MSS'.
  • Your cancer is at stage II or stage III and is located in the middle or lower part of the rectum (within 10 cm of the anus).
  • You have not had any previous treatment for this cancer.
  • You are in good general health (can carry out daily activities, adequate organ function).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07847229Not yet recruiting· Phase 2
Short radiation plus chemo with immunotherapy for rectal cancer

This study compares two treatment approaches for patients with locally advanced rectal cancer. One group gets a short course of radiation followed by chemotherapy combined with an immunotherapy drug called a PD-1 inhibitor, while the other group gets radiation and chemotherapy alone. The trial aims to see if the PD-1 inhibitor improves outcomes and whether a natural substance in the blood called beta-hydroxybutyrate can predict response.

Wuhan, Hubei
NCT06832917Not yet recruiting· Phase 3
Short-course radiation plus immunotherapy and chemo before surgery for rectal cancer

This trial tests a new treatment sequence for locally advanced rectal cancer: a short course of radiation followed by a combination of immunotherapy (cadonilimab) and chemotherapy (mFOLFOX6) before surgery. The goal is to shrink the tumor more effectively and potentially improve outcomes.

NCT07394192Not yet recruiting· Phase 2
Shorter radiation with immunotherapy for stage II-III rectal cancer

This trial tests a shorter course of radiation therapy that avoids lymph nodes, followed by an immunotherapy drug, for patients with stage II or III rectal cancer that has not spread. It aims to improve outcomes while reducing side effects.

NCT07068763Recruiting· Phase 2
Short radiation plus drugs for early rectal cancer

This trial tests a combination of short-course radiation, chemotherapy (capecitabine), and two immunotherapy drugs (PD-1 and CTLA-4 inhibitors) for people with early-stage rectal cancer who want to avoid surgery and keep their anus. The goal is to see if this treatment can shrink the tumor enough to avoid major surgery.

Hangzhou, Zhejiang
NCT06958432Recruiting· Phase 2/Phase 3
Shorter radiation before chemo and immunotherapy for rectal cancer

This trial tests a shorter course of radiation before chemotherapy and an immunotherapy drug to shrink mid-to-lower rectal cancer that has not spread. The goal is to improve treatment response and reduce side effects, potentially allowing for less invasive surgery.

Guangzhou, Guangdong
NCT07505472Recruiting· Phase 2/Phase 3
Short radiation plus chemo and immunotherapy for high-risk rectal cancer

This trial tests a new approach for people with locally advanced rectal cancer that has high-risk features. It combines short-course radiation with chemotherapy (CapeOX) and the immunotherapy drug toripalimab, with or without another drug called surufatinib, before surgery. The goal is to see if adding these drugs helps shrink the tumor and improve outcomes.

Changchun, Jilin

Hear when a new Rectal Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.