Short radiation plus two drugs for rectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a new combination of short-course radiation, a targeted therapy called fruquintinib, and an immunotherapy (PD-1 antibody) as a treatment before surgery for certain types of rectal cancer. The goal is to see if this approach can shrink tumors and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have rectal adenocarcinoma (a type of rectal cancer) that is pMMR or MSS type (not caused by a specific inherited gene).
- Your cancer is stage II (tumor through muscle wall, no lymph node spread) or stage III (spread to nearby lymph nodes).
- Your tumor is in the middle or lower rectum, less than 10 cm from the anal opening.
- You are between 18 and 75 years old and have not had any prior cancer treatment.
- Your overall health is good (ECOG score 0-1), and your vital organs function within acceptable ranges.
- If you are a woman able to have children, you agree to use effective birth control.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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