Methotrexate vs placebo for adults with eczema
Treatments studied
Part of Immune system & allergy, Skin clinical trials.
This trial tests if methotrexate, a medication that calms the immune system, can help adults with moderate-to-severe eczema that hasn't improved with creams or other treatments. You'll either receive methotrexate or a placebo to see which works better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have had eczema for at least 12 months and it's moderate to severe, covering a large area of your body.
- You've tried strong prescription creams or had other treatments like cyclosporine, but they didn't work well enough.
- You are 18 or older (adult) and willing to use reliable birth control if there's any chance of pregnancy.
- You have not taken methotrexate before.
- You do not have serious liver, kidney, or blood problems, active infections like tuberculosis, hepatitis, or HIV.
- You haven't used other eczema treatments like certain pills or injections (e.g., dupilumab) in the last few weeks or months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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